Control of Fetal Hemoglobin Levels By NFI Transcription Factors
نویسندگان
چکیده
منابع مشابه
Stimulation of BKV DNA replication by NFI-family transcription factors
1. Department of Biochemistry and Genetics Area Program, University of MissouriColumbia, Columbia, Missouri, 65211 USA; 2. Centre for Chromosome Biology, School of Natural Sciences, National University of Ireland, Galway, Galway, Ireland; current address: Laboratory of Infectious Disease, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, Maryland, US...
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The ingested nitrates sourced from tap water, food, chemicals and pharmaceuticals areconverted to nitrites in the body surfaces by bacteria and then, the nitrite ions can lead thestructural changing in hemoglobin. In the present work, aggregation of the purified hemoglobinin adult (HbA) and in fetus or newborn (HbF) in the presence of nitrite ions were studied.Hemoglobin aggregation was perform...
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5. Warren RJ, Moss DW. An automated continuous-monitoring procedure for the determination of acid phosphatase activity in serum. Clin Chim Acta 77, 179-188 (1977). 6. Gundlach G, Muhlhausen B. Untersuchungen zur Kupplung des 1-Naphthols mit Fast-red-TR. J Clin Chem Clin Biochem 18, 603-610 (1980). 7. Babson AL, Read PA. A new assay for prostatic acid phosphatase in serum. Am J Clin Pathol 32, 8...
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Fetal hemoglobin (Hb F) is an important genetic modulator of the beta-hemoglobinopathies. The regulation of Hb F levels is influenced by transcription factors. We used phylogenetic footprinting to screen transcription factors that have binding sites in HBG1 and HBG2 genes' noncoding regions in order to know the genetic determinants of the Hb F expression. Our analysis showed 354 conserved motif...
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ژورنال
عنوان ژورنال: Blood
سال: 2020
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2020-136167